A1 Refereed original research article in a scientific journal
Bifidobacterium and Lactobacillus DNA in the human placenta
Authors: Satokari R, Grönroos T, Laitinen K, Salminen S, Isolauri E
Publisher: WILEY-BLACKWELL PUBLISHING, INC
Publication year: 2009
Journal: Letters in Applied Microbiology
Journal name in source: LETTERS IN APPLIED MICROBIOLOGY
Journal acronym: LETT APPL MICROBIOL
Volume: 48
Issue: 1
First page : 8
Last page: 12
Number of pages: 5
ISSN: 0266-8254
DOI: https://doi.org/10.1111/j.1472-765X.2008.02475.x
Abstract
Bacterial DNA contains unmethylated CpG oligodeoxynucleotide motifs which induce immune effects. Specific CpG motifs activate Toll-like receptor 9 and subsequently trigger Th-1-type immune responses. Although the newborn infant is considered immunologically immature, exposure by bacterial DNA may programme the infant's immune development during foetal life earlier than previously considered.
Bacterial DNA contains unmethylated CpG oligodeoxynucleotide motifs which induce immune effects. Specific CpG motifs activate Toll-like receptor 9 and subsequently trigger Th-1-type immune responses. Although the newborn infant is considered immunologically immature, exposure by bacterial DNA may programme the infant's immune development during foetal life earlier than previously considered.
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