The ''thio effect' on the hydrolysis and transesterification of ribonucleoside phosphoesters



: Oivanen M, Ora M, Lonnberg H

Publisher: INST ORGANIC CHEM AND BIOCHEM

: 1996

: Collection of Czechoslovak Chemical Communications

: COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS

: COLLECT CZECH CHEM C

: 61

: S1

: S4

: 4

: 0010-0765


The effects that replacing one of the non-bridging oxygens of ribonucleoside phosphoesters with sulfur exerts on the kinetics of phosphoester hydrolysis and intramolecular transesterification under various conditions are discussed. The experimental examples refer to the phosphoromonothioate analogs of uridylyl(3',5')uridine, uridine 2',3'-cyclic monophosphate, and uridine 2'- and 3'-monophosphates.



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