B1 Non-refereed article in a scientific journal
The ''thio effect' on the hydrolysis and transesterification of ribonucleoside phosphoesters
Authors: Oivanen M, Ora M, Lonnberg H
Publisher: INST ORGANIC CHEM AND BIOCHEM
Publication year: 1996
Journal:: Collection of Czechoslovak Chemical Communications
Journal name in source: COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS
Journal acronym: COLLECT CZECH CHEM C
Volume: 61
First page : S1
Last page: S4
Number of pages: 4
ISSN: 0010-0765
Abstract
The effects that replacing one of the non-bridging oxygens of ribonucleoside phosphoesters with sulfur exerts on the kinetics of phosphoester hydrolysis and intramolecular transesterification under various conditions are discussed. The experimental examples refer to the phosphoromonothioate analogs of uridylyl(3',5')uridine, uridine 2',3'-cyclic monophosphate, and uridine 2'- and 3'-monophosphates.
The effects that replacing one of the non-bridging oxygens of ribonucleoside phosphoesters with sulfur exerts on the kinetics of phosphoester hydrolysis and intramolecular transesterification under various conditions are discussed. The experimental examples refer to the phosphoromonothioate analogs of uridylyl(3',5')uridine, uridine 2',3'-cyclic monophosphate, and uridine 2'- and 3'-monophosphates.
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