Five-year follow-up of 11C-PIB uptake in Alzheimer’s disease and MCI



: Kemppainen NM, Scheinin NM, Koivunen J, Johansson J, Toivonen JT, Någren K, Rokka J, Karrasch M, Parkkola R, Rinne JO

Publisher: Springer-Verlag Berlin Heidelberg

: 2014

: European Journal of Nuclear Medicine and Molecular Imaging

: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

: EUR J NUCL MED MOL I

: 41

: 2

: 283

: 289

: 7

: 1619-7070

: 1619-7089

DOI: https://doi.org/10.1007/s00259-013-2562-0


Our results revealed a significant increase in amyloid load even at the time of AD diagnosis in some of the MCI patients who converted. A positive [C-11]PIB scan at baseline in MCI patients strongly predicted future conversion to AD but a negative PIB scan in MCI patients did not exclude future conversion. The results suggest that there is wide individual variation in the brain amyloid load in MCI, and in the course of amyloid accumulation in relation to the clinical diagnosis of AD.



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