A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Five-year follow-up of 11C-PIB uptake in Alzheimer’s disease and MCI
Tekijät: Kemppainen NM, Scheinin NM, Koivunen J, Johansson J, Toivonen JT, Någren K, Rokka J, Karrasch M, Parkkola R, Rinne JO
Kustantaja: Springer-Verlag Berlin Heidelberg
Julkaisuvuosi: 2014
Journal: European Journal of Nuclear Medicine and Molecular Imaging
Tietokannassa oleva lehden nimi: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
Lehden akronyymi: EUR J NUCL MED MOL I
Vuosikerta: 41
Numero: 2
Aloitussivu: 283
Lopetussivu: 289
Sivujen määrä: 7
ISSN: 1619-7070
eISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-013-2562-0
Tiivistelmä
Our results revealed a significant increase in amyloid load even at the time of AD diagnosis in some of the MCI patients who converted. A positive [C-11]PIB scan at baseline in MCI patients strongly predicted future conversion to AD but a negative PIB scan in MCI patients did not exclude future conversion. The results suggest that there is wide individual variation in the brain amyloid load in MCI, and in the course of amyloid accumulation in relation to the clinical diagnosis of AD.
Our results revealed a significant increase in amyloid load even at the time of AD diagnosis in some of the MCI patients who converted. A positive [C-11]PIB scan at baseline in MCI patients strongly predicted future conversion to AD but a negative PIB scan in MCI patients did not exclude future conversion. The results suggest that there is wide individual variation in the brain amyloid load in MCI, and in the course of amyloid accumulation in relation to the clinical diagnosis of AD.
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