A1 Refereed original research article in a scientific journal
Five-year follow-up of 11C-PIB uptake in Alzheimer’s disease and MCI
Authors: Kemppainen NM, Scheinin NM, Koivunen J, Johansson J, Toivonen JT, Någren K, Rokka J, Karrasch M, Parkkola R, Rinne JO
Publisher: Springer-Verlag Berlin Heidelberg
Publication year: 2014
Journal: European Journal of Nuclear Medicine and Molecular Imaging
Journal name in source: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
Journal acronym: EUR J NUCL MED MOL I
Volume: 41
Issue: 2
First page : 283
Last page: 289
Number of pages: 7
ISSN: 1619-7070
eISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-013-2562-0(external)
Abstract
Our results revealed a significant increase in amyloid load even at the time of AD diagnosis in some of the MCI patients who converted. A positive [C-11]PIB scan at baseline in MCI patients strongly predicted future conversion to AD but a negative PIB scan in MCI patients did not exclude future conversion. The results suggest that there is wide individual variation in the brain amyloid load in MCI, and in the course of amyloid accumulation in relation to the clinical diagnosis of AD.
Our results revealed a significant increase in amyloid load even at the time of AD diagnosis in some of the MCI patients who converted. A positive [C-11]PIB scan at baseline in MCI patients strongly predicted future conversion to AD but a negative PIB scan in MCI patients did not exclude future conversion. The results suggest that there is wide individual variation in the brain amyloid load in MCI, and in the course of amyloid accumulation in relation to the clinical diagnosis of AD.
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