Intrahepatic cholestasis of pregnancy: observational study of the treatment with low-dose ursodeoxycholic acid
: Joutsiniemi T, Timonen S, Linden M, Suvitie P, Ekblad U
Publisher: BIOMED CENTRAL LTD
: 2015
: BMC Gastroenterology
: BMC GASTROENTEROLOGY
: BMC GASTROENTEROL
: ARTN 92
: 15
: 7
: 1471-230X
DOI: https://doi.org/10.1186/s12876-015-0324-0
Conclusions: Preterm labour was associated in severe ICP (total BA > 40 mu mol/l), ALT levels were also significantly higher and ICP was diagnosed earlier (p < 0.05). Apgar scores were lower in preterm babies (p < 0.05), but umbilical artery pHvalues were not significantly lower. UDCA was well tolerated by pregnant women. With low-dose UDCA treatment the obstetric outcome was good. We still recommend careful obstetrical follow-up.