Intrahepatic cholestasis of pregnancy: observational study of the treatment with low-dose ursodeoxycholic acid - UTU Tutkimustietojärjestelmä

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Intrahepatic cholestasis of pregnancy: observational study of the treatment with low-dose ursodeoxycholic acid

Tekijät: Joutsiniemi T, Timonen S, Linden M, Suvitie P, Ekblad U

Kustantaja: BIOMED CENTRAL LTD

Julkaisuvuosi: 2015

Journal: BMC Gastroenterology

Tietokannassa oleva lehden nimi: BMC GASTROENTEROLOGY

Lehden akronyymi: BMC GASTROENTEROL

Artikkelin numero: ARTN 92

Vuosikerta: 15

Sivujen määrä: 7

ISSN: 1471-230X

DOI: https://doi.org/10.1186/s12876-015-0324-0

Tiivistelmä

Conclusions: Preterm labour was associated in severe ICP (total BA > 40 mu mol/l), ALT levels were also significantly higher and ICP was diagnosed earlier (p < 0.05). Apgar scores were lower in preterm babies (p < 0.05), but umbilical artery pHvalues were not significantly lower. UDCA was well tolerated by pregnant women. With low-dose UDCA treatment the obstetric outcome was good. We still recommend careful obstetrical follow-up.