Intrahepatic cholestasis of pregnancy: observational study of the treatment with low-dose ursodeoxycholic acid - UTU Research Portal

A1 Refereed original research article in a scientific journal

Intrahepatic cholestasis of pregnancy: observational study of the treatment with low-dose ursodeoxycholic acid

Authors: Joutsiniemi T, Timonen S, Linden M, Suvitie P, Ekblad U

Publisher: BIOMED CENTRAL LTD

Publication year: 2015

Journal: BMC Gastroenterology

Journal name in source: BMC GASTROENTEROLOGY

Journal acronym: BMC GASTROENTEROL

Article number: ARTN 92

Volume: 15

Number of pages: 7

ISSN: 1471-230X

DOI: https://doi.org/10.1186/s12876-015-0324-0(external)

Abstract

Conclusions: Preterm labour was associated in severe ICP (total BA > 40 mu mol/l), ALT levels were also significantly higher and ICP was diagnosed earlier (p < 0.05). Apgar scores were lower in preterm babies (p < 0.05), but umbilical artery pHvalues were not significantly lower. UDCA was well tolerated by pregnant women. With low-dose UDCA treatment the obstetric outcome was good. We still recommend careful obstetrical follow-up.