The predictive adaptive response and metabolic syndrome: challenges for the hypothesis



: Rickard IJ, Lummaa V

Publisher: ELSEVIER SCIENCE LONDON

: 2007

: Trends in Endocrinology and Metabolism

: TRENDS IN ENDOCRINOLOGY AND METABOLISM

: TRENDS ENDOCRIN MET

: 18

: 3

: 94

: 99

: 6

: 1043-2760

DOI: https://doi.org/10.1016/j.tem.2007.02.004


In humans and other mammals, maternal undernutrition or stress during gestation results in small offspring with permanently altered metabolism and tissue composition. It has been suggested that such responses might exist because in utero conditions provide a reliable 'prediction' of the environmental conditions that foetuses will eventually be exposed to during adulthood. Thus, some developmental responses to the early environment might improve an individual's evolutionary success in a similar future environment.



Last updated on 2024-26-11 at 17:04