A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
The predictive adaptive response and metabolic syndrome: challenges for the hypothesis
Tekijät: Rickard IJ, Lummaa V
Kustantaja: ELSEVIER SCIENCE LONDON
Julkaisuvuosi: 2007
Journal: Trends in Endocrinology and Metabolism
Tietokannassa oleva lehden nimi: TRENDS IN ENDOCRINOLOGY AND METABOLISM
Lehden akronyymi: TRENDS ENDOCRIN MET
Vuosikerta: 18
Numero: 3
Aloitussivu: 94
Lopetussivu: 99
Sivujen määrä: 6
ISSN: 1043-2760
DOI: https://doi.org/10.1016/j.tem.2007.02.004
Tiivistelmä
In humans and other mammals, maternal undernutrition or stress during gestation results in small offspring with permanently altered metabolism and tissue composition. It has been suggested that such responses might exist because in utero conditions provide a reliable 'prediction' of the environmental conditions that foetuses will eventually be exposed to during adulthood. Thus, some developmental responses to the early environment might improve an individual's evolutionary success in a similar future environment.
In humans and other mammals, maternal undernutrition or stress during gestation results in small offspring with permanently altered metabolism and tissue composition. It has been suggested that such responses might exist because in utero conditions provide a reliable 'prediction' of the environmental conditions that foetuses will eventually be exposed to during adulthood. Thus, some developmental responses to the early environment might improve an individual's evolutionary success in a similar future environment.
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