A1 Refereed original research article in a scientific journal
Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia
Authors: Mucci L., West C., Koutros S., Cancel-Tassin G., Maehle L., Sorensen K., Travis R., Neal D., Batra J., Tangen C., Gronberg H., Clements J., Albanes D., Schleutker J., Wolk A., Weinstein S., Penney K., Park J., Stanford J., Cybulski C., Nordestgaard B., Brenner H., Maier C., Kim J., Hamilton R., Ingles S., Rosenstein B., Lu Y., Giles G., Kibel A., Vega A., Kogevinas M., Dominguez M., Townsend P., Claessens F., Usmani N., Menegaux F., Roobol M., De Ruyck K., Neuhausen S., Teixeira M., John E., Kaneva R., Lessel D., Newcomb L., Razack A., Vijayakrishnan J., Kumar R., Law P., Harrison C., Allan J., Broderick P., Studd J., Holroyd A., Kinnersley B., Sheridan E., Kinsey S., Irving J., Thompson P., Vora A., Moorman A., Rachakonda S., Roman E., Pharaoh P., Dunning A., Jöckel K., Easton D., Nöthen M., Heilmann-Heimbach S., Koehler R., Hoffmann P., Pashayan N., Greaves M., Kote-Jarai Z., Muir K., Swerdlow A., Eeles R., Peto J., Canzian F., Haiman C., Henderson B., Houlston R., Hemminki K., Stanulla M., Schrappe M., Bartram C., Zimmerman M., Stevens V., Chanock S., Wiklund F., Conti D., Berndt S., Olama A., Schumacher F., Benlloch S.
Publisher: Nature Publishing Group
Publication year: 2018
Journal: Nature Communications
Journal name in source: Nature Communications
Article number: 1340
Volume: 9
Number of pages: 9
ISSN: 2041-1723
DOI: https://doi.org/10.1038/s41467-018-03178-z
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/31531455
Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a GWAS and conduct a meta-analysis with two existing GWAS, totaling 2442 cases and 14,609 controls. We identify risk loci for BCP-ALL at 8q24.21 (rs28665337, P = 3.86 × 10−9, odds ratio (OR) = 1.34) and for ETV6-RUNX1 fusion-positive BCP-ALL at 2q22.3 (rs17481869, P = 3.20 × 10−8, OR = 2.14). Our findings provide further insights into genetic susceptibility to ALL and its biology.
Downloadable publication This is an electronic reprint of the original article. |  |
