A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia
Tekijät: Mucci L., West C., Koutros S., Cancel-Tassin G., Maehle L., Sorensen K., Travis R., Neal D., Batra J., Tangen C., Gronberg H., Clements J., Albanes D., Schleutker J., Wolk A., Weinstein S., Penney K., Park J., Stanford J., Cybulski C., Nordestgaard B., Brenner H., Maier C., Kim J., Hamilton R., Ingles S., Rosenstein B., Lu Y., Giles G., Kibel A., Vega A., Kogevinas M., Dominguez M., Townsend P., Claessens F., Usmani N., Menegaux F., Roobol M., De Ruyck K., Neuhausen S., Teixeira M., John E., Kaneva R., Lessel D., Newcomb L., Razack A., Vijayakrishnan J., Kumar R., Law P., Harrison C., Allan J., Broderick P., Studd J., Holroyd A., Kinnersley B., Sheridan E., Kinsey S., Irving J., Thompson P., Vora A., Moorman A., Rachakonda S., Roman E., Pharaoh P., Dunning A., Jöckel K., Easton D., Nöthen M., Heilmann-Heimbach S., Koehler R., Hoffmann P., Pashayan N., Greaves M., Kote-Jarai Z., Muir K., Swerdlow A., Eeles R., Peto J., Canzian F., Haiman C., Henderson B., Houlston R., Hemminki K., Stanulla M., Schrappe M., Bartram C., Zimmerman M., Stevens V., Chanock S., Wiklund F., Conti D., Berndt S., Olama A., Schumacher F., Benlloch S.
Kustantaja: Nature Publishing Group
Julkaisuvuosi: 2018
Journal: Nature Communications
Tietokannassa oleva lehden nimi: Nature Communications
Artikkelin numero: 1340
Vuosikerta: 9
Sivujen määrä: 9
ISSN: 2041-1723
DOI: https://doi.org/10.1038/s41467-018-03178-z
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/31531455
Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a GWAS and conduct a meta-analysis with two existing GWAS, totaling 2442 cases and 14,609 controls. We identify risk loci for BCP-ALL at 8q24.21 (rs28665337, P = 3.86 × 10−9, odds ratio (OR) = 1.34) and for ETV6-RUNX1 fusion-positive BCP-ALL at 2q22.3 (rs17481869, P = 3.20 × 10−8, OR = 2.14). Our findings provide further insights into genetic susceptibility to ALL and its biology.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
