A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
SYNTHESIS OF 7-SUBSTITUTED 3-beta-D-RIBOFURANOSYL-3H-IMIDAZO[2,1-i]PURINES
Tekijät: Karskela T, Klika KD, Lonnberg H
Kustantaja: INST ORGANIC CHEM AND BIOCHEM
Julkaisuvuosi: 2011
Journal: Collection of Czechoslovak Chemical Communications
Tietokannassa oleva lehden nimi: COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS
Lehden akronyymi: COLLECT CZECH CHEM C
Numero sarjassa: 8
Vuosikerta: 76
Numero: 8
Aloitussivu: 1043
Lopetussivu: 1054
Sivujen määrä: 12
ISSN: 0010-0765
DOI: https://doi.org/10.1135/cccc2011069
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/Publication/3140896
A method for the synthesis of 7-substituted 3-beta-D-ribofuranosyl-3H-imidazo[2,1-i]purines has been devised whereby compounds were prepared in a few steps from a common intermediate, 3-(2',3'-O-isopropylidene-beta-D-ribofuranosyl)-3H-imidazo[2,1-i]purine-7-carbaldehyde, obtained from the reaction of 2',3'-O-isopropylideneadenosine with bromomalonaldehyde. The formyl group of the carbaldehyde was subsequently reductively aminated and the resulting secondary amines were then further derivatized either by acylation, lactamization or reductive alkylation.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
