A1 Refereed original research article in a scientific journal
SYNTHESIS OF 7-SUBSTITUTED 3-beta-D-RIBOFURANOSYL-3H-IMIDAZO[2,1-i]PURINES
Authors: Karskela T, Klika KD, Lonnberg H
Publisher: INST ORGANIC CHEM AND BIOCHEM
Publication year: 2011
Journal: Collection of Czechoslovak Chemical Communications
Journal name in source: COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS
Journal acronym: COLLECT CZECH CHEM C
Number in series: 8
Volume: 76
Issue: 8
First page : 1043
Last page: 1054
Number of pages: 12
ISSN: 0010-0765
DOI: https://doi.org/10.1135/cccc2011069
Self-archived copy’s web address: https://research.utu.fi/converis/portal/Publication/3140896
A method for the synthesis of 7-substituted 3-beta-D-ribofuranosyl-3H-imidazo[2,1-i]purines has been devised whereby compounds were prepared in a few steps from a common intermediate, 3-(2',3'-O-isopropylidene-beta-D-ribofuranosyl)-3H-imidazo[2,1-i]purine-7-carbaldehyde, obtained from the reaction of 2',3'-O-isopropylideneadenosine with bromomalonaldehyde. The formyl group of the carbaldehyde was subsequently reductively aminated and the resulting secondary amines were then further derivatized either by acylation, lactamization or reductive alkylation.
Keywords:
Heterocycles, NMR spectroscopy, Nucleosides, Purine bases
Downloadable publication This is an electronic reprint of the original article. |  |
