A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Binge eating disorder and morbid obesity are associated with lowered mu-opioid receptor availability in the brain
Tekijät: Juho Joutsa, Henry K. Karlsson, Joonas Majuri,, Pirjo Nuutila, Semi Helin, Valtteri Kaasinen, Lauri Nummenmaa
Kustantaja: ELSEVIER IRELAND LTD
Julkaisuvuosi: 2018
Journal: Psychiatry Research: Neuroimaging
Tietokannassa oleva lehden nimi: PSYCHIATRY RESEARCH-NEUROIMAGING
Lehden akronyymi: PSYCHIAT RES-NEUROIM
Vuosikerta: 276
Aloitussivu: 41
Lopetussivu: 45
Sivujen määrä: 5
ISSN: 0925-4927
eISSN: 1872-7506
DOI: https://doi.org/10.1016/j.pscychresns.2018.03.006
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/31293055
Both morbid obesity and binge eating disorder (BED) have previously been linked with aberrant brain opioid function. Behaviorally these two conditions are however different suggesting also differences in neurotransmitter function. Here we directly compared mu-opioid receptor (MOR) availability between morbidly obese and BED subjects. Seven BED and nineteen morbidly obese (non-BED) patients, and thirty matched control subjects underwent positron emission tomography (PET) with MOR-specific ligand [C-11]carfentanil. Both subjects with morbid obesity and BED had widespread reduction in [C-11]carfentanil binding compared to control subjects. However, there was no significant difference in brain MOR binding between subjects with morbid obesity and BED. Thus, our results indicate that there is common brain opioid abnormally in behaviorally different eating disorders involving obesity.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
