A1 Refereed original research article in a scientific journal
Binge eating disorder and morbid obesity are associated with lowered mu-opioid receptor availability in the brain
Authors: Juho Joutsa, Henry K. Karlsson, Joonas Majuri,, Pirjo Nuutila, Semi Helin, Valtteri Kaasinen, Lauri Nummenmaa
Publisher: ELSEVIER IRELAND LTD
Publication year: 2018
Journal: Psychiatry Research: Neuroimaging
Journal name in source: PSYCHIATRY RESEARCH-NEUROIMAGING
Journal acronym: PSYCHIAT RES-NEUROIM
Volume: 276
First page : 41
Last page: 45
Number of pages: 5
ISSN: 0925-4927
eISSN: 1872-7506
DOI: https://doi.org/10.1016/j.pscychresns.2018.03.006
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/31293055
Both morbid obesity and binge eating disorder (BED) have previously been linked with aberrant brain opioid function. Behaviorally these two conditions are however different suggesting also differences in neurotransmitter function. Here we directly compared mu-opioid receptor (MOR) availability between morbidly obese and BED subjects. Seven BED and nineteen morbidly obese (non-BED) patients, and thirty matched control subjects underwent positron emission tomography (PET) with MOR-specific ligand [C-11]carfentanil. Both subjects with morbid obesity and BED had widespread reduction in [C-11]carfentanil binding compared to control subjects. However, there was no significant difference in brain MOR binding between subjects with morbid obesity and BED. Thus, our results indicate that there is common brain opioid abnormally in behaviorally different eating disorders involving obesity.
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