A1 Refereed original research article in a scientific journal

Microparticle - based platform for point-of-care immunoassays



Authors: Teppo Salminen, Etvi Juntunen, Merja Lahdenranta, Iida Martiskainen, Sheikh M. Talha, Kim Pettersson

Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE

Publication year: 2018

Journal: Analytical Biochemistry

Journal name in source: ANALYTICAL BIOCHEMISTRY

Journal acronym: ANAL BIOCHEM

Volume: 548

First page : 66

Last page: 68

Number of pages: 3

ISSN: 0003-2697

eISSN: 1096-0309

DOI: https://doi.org/10.1016/j.ab.2018.02.021

Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/31197303


Abstract
There is a need for quantitative and sensitive, yet simple point-of-care immunoassays: We have developed a point-of-care microparticle-based immunoassay platform which combines the performance of a microliter well based assay with the usability of a rapid assay. The platform contained a separate reaction and detection chambers and microparticles for the solid-phase. Photoluminescent up-converting nanoparticles (UCNPs) were used as labels. The platform was tested with a cardiac troponin I assay, and a limit of detection of 19.7 ng/L was obtained. This study demonstrates the feasibility of developing point-of-care assays on the new platform for various analytes of interests.

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Last updated on 2024-26-11 at 11:24