Role of the potassium/lysine cationic center in catalysis and functional asymmetry in membrane-bound pyrophosphatases



: Artukka E, Luoto HH, Baykov AA, Lahti R, Malinen AM

Publisher: Portland Press Ltd.

: 2018

: Biochemical Journal

: The Biochemical journal

: Biochem J

: 475

: 6

: 1141

: 1158

: 18

: 1470-8728

DOI: https://doi.org/10.1042/BCJ20180071

: https://research.utu.fi/converis/portal/detail/Publication/30734070


/Lys center was identified as part of the mechanism underlying this effect. These findings suggest that the mPPase homodimer possesses an asymmetry of active site performance that may be an ancient prototype of the rotational binding-change mechanism of F-type ATPases.

Last updated on 2024-26-11 at 20:04