Humoral response to John Cunningham virus during pregnancy in multiple sclerosis

: M. Saraste, S. Atula, K. Hedman, S. Hurme, A. Jalkanen, M. Sneck, H.-M. Surcel, A.H. Maghzi, L. Airas

Publisher: Elsevier B.V.

: 2018

: Multiple Sclerosis and Related Disorders

: 21

: 11

: 18

: 8

: 2211-0348

: 2211-0356

DOI: https://doi.org/10.1016/j.msard.2018.02.008

: https://research.utu.fi/converis/portal/detail/Publication/30545669

Conclusions

JCV-Ab levels remain unaltered during MS pregnancy, while the total IgG concentration is reduced/diluted due to increasing plasma volumes during the course of pregnancy. This may imply a biologically significant alteration in the immune response to JCV during MS pregnancy.

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