Adventures in radiosynthesis of clinical grade [68Ga]Ga-DOTA-Siglec-9

: Käkelä Meeri, Luoto Pauliina, Viljanen Tapio, Virtanen Helena, Liljenbäck Heidi, Jalkanen Sirpa, Knuuti Juhani, Roivainen Anne, Li Xiang-Guo

Publisher: ROYAL SOC CHEMISTRY

: 2018

: RSC Advances

: RSC ADVANCES

: RSC ADV

: 8

: 15

: 8051

: 8056

: 6

: 2046-2069

DOI: https://doi.org/10.1039/c7ra12423f

: https://research.utu.fi/converis/portal/detail/Publication/30431180

We finally managed to establish a protocol for generating Good Manufacturing Practice (GMP)-grade gallium-68-labelled 1,4,7,0-tetraazacyclododecane-1,4,7,10-tetraacetic acid conjugated sialic acid-binding immunoglobulin-like lectin 9 motif containing peptide ([Ga-68]Ga-DOTA-Siglec-9), the first radiopharmaceutical for positron emission tomography imaging of vascular adhesion protein 1.

c7ra12423f.pdf