Template-Triggered Emergence of a Self-Replicator from a Dynamic Combinatorial Library



: Nowak P, Colomb-Delsuc M, Otto S, Li JW

Publisher: AMER CHEMICAL SOC

: 2015

: Journal of the American Chemical Society

: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

: J AM CHEM SOC

: 137

: 34

: 10965

: 10969

: 5

: 0002-7863

DOI: https://doi.org/10.1021/jacs.5b04380


Self-assembly of a specific member of a dynamic combinatorial library (DCL) may lead to self-replication of this molecule. However, if the concentration of the potential replicator in the DCL fails to exceed its critical aggregation concentration (CAC), then self-replication will not occur. We now show how addition of a template can raise the concentration of a library member-template complex beyond its CAC, leading to the onset of self-replication. Once in existence, the replicator aggregates promote further replication also in the absence of the template that induced the initial emergence of the replicator.

Last updated on 2024-26-11 at 13:40