A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Template-Triggered Emergence of a Self-Replicator from a Dynamic Combinatorial Library
Tekijät: Nowak P, Colomb-Delsuc M, Otto S, Li JW
Kustantaja: AMER CHEMICAL SOC
Julkaisuvuosi: 2015
Journal: Journal of the American Chemical Society
Tietokannassa oleva lehden nimi: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Lehden akronyymi: J AM CHEM SOC
Vuosikerta: 137
Numero: 34
Aloitussivu: 10965
Lopetussivu: 10969
Sivujen määrä: 5
ISSN: 0002-7863
DOI: https://doi.org/10.1021/jacs.5b04380
Tiivistelmä
Self-assembly of a specific member of a dynamic combinatorial library (DCL) may lead to self-replication of this molecule. However, if the concentration of the potential replicator in the DCL fails to exceed its critical aggregation concentration (CAC), then self-replication will not occur. We now show how addition of a template can raise the concentration of a library member-template complex beyond its CAC, leading to the onset of self-replication. Once in existence, the replicator aggregates promote further replication also in the absence of the template that induced the initial emergence of the replicator.
Self-assembly of a specific member of a dynamic combinatorial library (DCL) may lead to self-replication of this molecule. However, if the concentration of the potential replicator in the DCL fails to exceed its critical aggregation concentration (CAC), then self-replication will not occur. We now show how addition of a template can raise the concentration of a library member-template complex beyond its CAC, leading to the onset of self-replication. Once in existence, the replicator aggregates promote further replication also in the absence of the template that induced the initial emergence of the replicator.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
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