A1 Refereed original research article in a scientific journal
Template-Triggered Emergence of a Self-Replicator from a Dynamic Combinatorial Library
Authors: Nowak P, Colomb-Delsuc M, Otto S, Li JW
Publisher: AMER CHEMICAL SOC
Publication year: 2015
Journal: Journal of the American Chemical Society
Journal name in source: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Journal acronym: J AM CHEM SOC
Volume: 137
Issue: 34
First page : 10965
Last page: 10969
Number of pages: 5
ISSN: 0002-7863
DOI: https://doi.org/10.1021/jacs.5b04380
Abstract
Self-assembly of a specific member of a dynamic combinatorial library (DCL) may lead to self-replication of this molecule. However, if the concentration of the potential replicator in the DCL fails to exceed its critical aggregation concentration (CAC), then self-replication will not occur. We now show how addition of a template can raise the concentration of a library member-template complex beyond its CAC, leading to the onset of self-replication. Once in existence, the replicator aggregates promote further replication also in the absence of the template that induced the initial emergence of the replicator.
Self-assembly of a specific member of a dynamic combinatorial library (DCL) may lead to self-replication of this molecule. However, if the concentration of the potential replicator in the DCL fails to exceed its critical aggregation concentration (CAC), then self-replication will not occur. We now show how addition of a template can raise the concentration of a library member-template complex beyond its CAC, leading to the onset of self-replication. Once in existence, the replicator aggregates promote further replication also in the absence of the template that induced the initial emergence of the replicator.
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