Association Between Early-Life Antibiotic Use and the Risk of Islet or Celiac Disease Autoimmunity



: Kemppainen KM, Vehik K, Lynch KF, Larsson HE, Canepa RJ, Simell V, Koletzko S, Liu E, Simell OG, Toppari J, Ziegler AG, Rewers MJ, Lernmark Å, Hagopian WA, She JX, Akolkar B, Schatz DA, Atkinson MA, Blaser MJ, Krischer JP, Hyöty H, Agardh D, Triplett EW; Environmental Determinants of Diabetes in the Young (TEDDY) Study Group

: 2017

: JAMA Pediatrics

: 171

: 12

: 1217

: 1225

: 9

: 2168-6203

DOI: https://doi.org/10.1001/jamapediatrics.2017.2905


Conclusions and Relevance  The use of the most prescribed antibiotics during the first 4 years of life, regardless of geographic region, was not associated with the development of autoimmunity for T1D or CD. These results suggest that a risk of islet or tissue transglutaminase autoimmunity need not influence the recommendations for clinical use of antibiotics in young children at risk for T1D or CD



Last updated on 2024-26-11 at 11:50