Association Between Early-Life Antibiotic Use and the Risk of Islet or Celiac Disease Autoimmunity - UTU Research Portal

A1 Refereed original research article in a scientific journal

Association Between Early-Life Antibiotic Use and the Risk of Islet or Celiac Disease Autoimmunity

Authors: Kemppainen KM, Vehik K, Lynch KF, Larsson HE, Canepa RJ, Simell V, Koletzko S, Liu E, Simell OG, Toppari J, Ziegler AG, Rewers MJ, Lernmark Å, Hagopian WA, She JX, Akolkar B, Schatz DA, Atkinson MA, Blaser MJ, Krischer JP, Hyöty H, Agardh D, Triplett EW; Environmental Determinants of Diabetes in the Young (TEDDY) Study Group

Publication year: 2017

Journal: JAMA Pediatrics

Volume: 171

Issue: 12

First page : 1217

Last page: 1225

Number of pages: 9

ISSN: 2168-6203

DOI: https://doi.org/10.1001/jamapediatrics.2017.2905

Abstract

Conclusions and Relevance The use of the most prescribed antibiotics during the first 4 years of life, regardless of geographic region, was not associated with the development of autoimmunity for T1D or CD. These results suggest that a risk of islet or tissue transglutaminase autoimmunity need not influence the recommendations for clinical use of antibiotics in young children at risk for T1D or CD