Identification of quantitative trait loci influencing inflammation-mediated alveolar bone loss: insights into polygenic inheritance of host-biofilm disequilibria in periodontitis



: C. Sima, Q. Cheng, J. Rautava, C. Levesque, P. Sherman, M. Glogauer

Publisher: WILEY-BLACKWELL

: 2016

: Journal of Periodontal Research

: JOURNAL OF PERIODONTAL RESEARCH

: J PERIODONTAL RES

: 51

: 2

: 237

: 249

: 13

: 0022-3484

: 1600-0765

DOI: https://doi.org/10.1111/jre.12303


Conclusion: Our results indicate that complex host-biofilm interactions generate pathogenic states that extend beyond subgingival biofilms and periodontal tissues. Although no temporal relationship between the onset of iABL and microbiome changes were established, our findings suggest that host factors may be responsible for pathogenic shifts in subgingival biofilms when persistent and undisturbed.




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