Identification of quantitative trait loci influencing inflammation-mediated alveolar bone loss: insights into polygenic inheritance of host-biofilm disequilibria in periodontitis - UTU Tutkimustietojärjestelmä

A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä

Identification of quantitative trait loci influencing inflammation-mediated alveolar bone loss: insights into polygenic inheritance of host-biofilm disequilibria in periodontitis

Tekijät: C. Sima, Q. Cheng, J. Rautava, C. Levesque, P. Sherman, M. Glogauer

Kustantaja: WILEY-BLACKWELL

Julkaisuvuosi: 2016

Journal: Journal of Periodontal Research

Tietokannassa oleva lehden nimi: JOURNAL OF PERIODONTAL RESEARCH

Lehden akronyymi: J PERIODONTAL RES

Vuosikerta: 51

Numero: 2

Aloitussivu: 237

Lopetussivu: 249

Sivujen määrä: 13

ISSN: 0022-3484

eISSN: 1600-0765

DOI: https://doi.org/10.1111/jre.12303

Tiivistelmä

Conclusion: Our results indicate that complex host-biofilm interactions generate pathogenic states that extend beyond subgingival biofilms and periodontal tissues. Although no temporal relationship between the onset of iABL and microbiome changes were established, our findings suggest that host factors may be responsible for pathogenic shifts in subgingival biofilms when persistent and undisturbed.