Identification of quantitative trait loci influencing inflammation-mediated alveolar bone loss: insights into polygenic inheritance of host-biofilm disequilibria in periodontitis - UTU Research Portal

A1 Refereed original research article in a scientific journal

Identification of quantitative trait loci influencing inflammation-mediated alveolar bone loss: insights into polygenic inheritance of host-biofilm disequilibria in periodontitis

Authors: C. Sima, Q. Cheng, J. Rautava, C. Levesque, P. Sherman, M. Glogauer

Publisher: WILEY-BLACKWELL

Publication year: 2016

Journal: Journal of Periodontal Research

Journal name in source: JOURNAL OF PERIODONTAL RESEARCH

Journal acronym: J PERIODONTAL RES

Volume: 51

Issue: 2

First page : 237

Last page: 249

Number of pages: 13

ISSN: 0022-3484

eISSN: 1600-0765

DOI: https://doi.org/10.1111/jre.12303

Abstract

Conclusion: Our results indicate that complex host-biofilm interactions generate pathogenic states that extend beyond subgingival biofilms and periodontal tissues. Although no temporal relationship between the onset of iABL and microbiome changes were established, our findings suggest that host factors may be responsible for pathogenic shifts in subgingival biofilms when persistent and undisturbed.