A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms
Tekijät: Mack S, Coassin S, Rueedi R, Yousri NA, Seppala I, Gieger C, Schonherr S, Forer L, Erhart G, Marques-Vidal P, Ried JS, Waeber G, Bergmann S, Dahnhardt D, Stockl A, Raitakari OT, Khahonen M, Peters A, Meitinger T, Strauch K, Kedenko L, Paulweber B, Lehtimaki T, Hunt SC, Vollenweider P, Lamina C, Kronenberg F
Kustantaja: AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Julkaisuvuosi: 2017
Journal: Journal of Lipid Research
Tietokannassa oleva lehden nimi: JOURNAL OF LIPID RESEARCH
Lehden akronyymi: J LIPID RES
Vuosikerta: 58
Numero: 10
Aloitussivu: 1834
Lopetussivu: 1844
Sivujen määrä: 11
ISSN: 0022-2275
DOI: https://doi.org/10.1194/jlr.M076232
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/26622045
High lipoprotein (a) [Lp(a)] concentrations are an independent risk factor for cardiovascular outcomes. Concentrations are strongly influenced by apo(a) kringle IV repeat isoforms. We aimed to identify genetic loci associated with Lp(a) concentrations using data from five genome- wide association studies (n = 13,781). We identified 48 independent SNPs in the LPA and 1 SNP in the APOE gene region to be significantly associated with Lp(a) concentrations. We also adjusted for apo(a) isoforms to identify loci affecting Lp(a) levels independently from them, which resulted in 31 SNPs (30 in the LPA, 1 in the APOE gene region). Seven
Ladattava julkaisu This is an electronic reprint of the original article. |  |
