A1 Refereed original research article in a scientific journal

A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms



Authors: Mack S, Coassin S, Rueedi R, Yousri NA, Seppala I, Gieger C, Schonherr S, Forer L, Erhart G, Marques-Vidal P, Ried JS, Waeber G, Bergmann S, Dahnhardt D, Stockl A, Raitakari OT, Khahonen M, Peters A, Meitinger T, Strauch K, Kedenko L, Paulweber B, Lehtimaki T, Hunt SC, Vollenweider P, Lamina C, Kronenberg F

Publisher: AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC

Publication year: 2017

Journal: Journal of Lipid Research

Journal name in source: JOURNAL OF LIPID RESEARCH

Journal acronym: J LIPID RES

Volume: 58

Issue: 10

First page : 1834

Last page: 1844

Number of pages: 11

ISSN: 0022-2275

DOI: https://doi.org/10.1194/jlr.M076232

Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/26622045


Abstract
High lipoprotein (a) [Lp(a)] concentrations are an independent risk factor for cardiovascular outcomes. Concentrations are strongly influenced by apo(a) kringle IV repeat isoforms. We aimed to identify genetic loci associated with Lp(a) concentrations using data from five genome- wide association studies (n = 13,781). We identified 48 independent SNPs in the LPA and 1 SNP in the APOE gene region to be significantly associated with Lp(a) concentrations. We also adjusted for apo(a) isoforms to identify loci affecting Lp(a) levels independently from them, which resulted in 31 SNPs (30 in the LPA, 1 in the APOE gene region). Seven

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Last updated on 2024-26-11 at 15:43