Catalytically significant macrochelate formation in Zn2+ promoted hydrolysis of oligoribonucleotides: Model studies with chimeric phosphodiester/methylphosphonate oligomers



: Kuusela S, Lonnberg H

Publisher: MARCEL DEKKER INC

: 1998

: Nucleosides & nucleotides

: NUCLEOSIDES & NUCLEOTIDES

: NUCLEOS NUCLEOT

: 17

: 12

: 2417

: 2427

: 11

: 0732-8311

DOI: https://doi.org/10.1080/07328319808004328


The kinetics of Zn2+ promoted hydrolysis of chimeric oligonucleotides Up[Tp(Me)](3)T and Up[Tp(Me)](3)Tp was studied. The results were compared to those obtained with corresponding phosphodiester oligonucleotides, and discussed in terms of an oligonucleotide-metal ion macrochelate formation.



Last updated on 2024-26-11 at 20:35