A1 Refereed original research article in a scientific journal

Catalytically significant macrochelate formation in Zn2+ promoted hydrolysis of oligoribonucleotides: Model studies with chimeric phosphodiester/methylphosphonate oligomers



Authors: Kuusela S, Lonnberg H

Publisher: MARCEL DEKKER INC

Publication year: 1998

Journal: Nucleosides & nucleotides

Journal name in source: NUCLEOSIDES & NUCLEOTIDES

Journal acronym: NUCLEOS NUCLEOT

Volume: 17

Issue: 12

First page : 2417

Last page: 2427

Number of pages: 11

ISSN: 0732-8311

DOI: https://doi.org/10.1080/07328319808004328(external)


Abstract
The kinetics of Zn2+ promoted hydrolysis of chimeric oligonucleotides Up[Tp(Me)](3)T and Up[Tp(Me)](3)Tp was studied. The results were compared to those obtained with corresponding phosphodiester oligonucleotides, and discussed in terms of an oligonucleotide-metal ion macrochelate formation.


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