A1 Refereed original research article in a scientific journal

Catalytically significant macrochelate formation in Zn2+ promoted hydrolysis of oligoribonucleotides: Model studies with chimeric phosphodiester/methylphosphonate oligomers




AuthorsKuusela S, Lonnberg H

PublisherMARCEL DEKKER INC

Publication year1998

JournalNucleosides & nucleotides

Journal name in sourceNUCLEOSIDES & NUCLEOTIDES

Journal acronymNUCLEOS NUCLEOT

Volume17

Issue12

First page 2417

Last page2427

Number of pages11

ISSN0732-8311

DOIhttps://doi.org/10.1080/07328319808004328(external)


Abstract
The kinetics of Zn2+ promoted hydrolysis of chimeric oligonucleotides Up[Tp(Me)](3)T and Up[Tp(Me)](3)Tp was studied. The results were compared to those obtained with corresponding phosphodiester oligonucleotides, and discussed in terms of an oligonucleotide-metal ion macrochelate formation.


Research Areas



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