A1 Refereed original research article in a scientific journal
Catalytically significant macrochelate formation in Zn2+ promoted hydrolysis of oligoribonucleotides: Model studies with chimeric phosphodiester/methylphosphonate oligomers
Authors: Kuusela S, Lonnberg H
Publisher: MARCEL DEKKER INC
Publication year: 1998
Journal: Nucleosides & nucleotides
Journal name in source: NUCLEOSIDES & NUCLEOTIDES
Journal acronym: NUCLEOS NUCLEOT
Volume: 17
Issue: 12
First page : 2417
Last page: 2427
Number of pages: 11
ISSN: 0732-8311
DOI: https://doi.org/10.1080/07328319808004328(external)
Abstract
The kinetics of Zn2+ promoted hydrolysis of chimeric oligonucleotides Up[Tp(Me)](3)T and Up[Tp(Me)](3)Tp was studied. The results were compared to those obtained with corresponding phosphodiester oligonucleotides, and discussed in terms of an oligonucleotide-metal ion macrochelate formation.
The kinetics of Zn2+ promoted hydrolysis of chimeric oligonucleotides Up[Tp(Me)](3)T and Up[Tp(Me)](3)Tp was studied. The results were compared to those obtained with corresponding phosphodiester oligonucleotides, and discussed in terms of an oligonucleotide-metal ion macrochelate formation.