High angular resolution diffusion-weighted imaging in mild traumatic brain injury
: Mohammadian M, Roine T, Hirvonen J, Kurki T, Ala-Seppala H, Frantzen J, Katila A, Kyllönen A, Maanpää HR, Posti J, Takala R, Tallus J, Tenovuo O
Publisher: ELSEVIER SCI LTD
: 2017
: NeuroImage: Clinical
: NEUROIMAGE-CLINICAL
: NEUROIMAGE-CLIN
: 13
: 174
: 180
: 7
: 2213-1582
DOI: https://doi.org/10.1016/j.nicl.2016.11.016
: https://research.utu.fi/converis/portal/detail/Publication/25867175
We sought to investigate white matter abnormalities in mild traumatic brain injury (mTBI) using diffusion-weighted magnetic resonance imaging (DW-MRI). We applied a global approach based on tract-based spatial statistics skeleton as well as constrained spherical deconvolution tractography.DW-MRI was performed on 102 patients with mTBI within two months post-injury and 30 control subjects. A robust global approach considering only the voxels with a single-fiber configuration was used in addition to global analysis of the tract skeleton and probabilistic whole-brain tractography. In addition, we assessed whether the microstructural parameters correlated with age, time from injury, patient's outcome and white matter MRI hyperintensities. We found that whole-brain global approach restricted to single-fiber voxels showed significantly decreased fractional anisotropy (FA) (p = 0.002) and increased radial diffusivity (p = 0.011) in patients with mTBI compared with controls. The results restricted to single-fiber voxels were more significant and reproducible than those with the complete tract skeleton or the whole-brain tractography. FA correlated with patient outcomes, white matter hyperintensities and age. No correlation was observed between FA and time of scan post-injury. In conclusion, the global approach could be a promising imaging biomarker to detect white matter abnormalities following traumatic brain injury. (C) 2016 The Authors. Published by Elsevier Inc.
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