A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
High angular resolution diffusion-weighted imaging in mild traumatic brain injury
Tekijät: Mohammadian M, Roine T, Hirvonen J, Kurki T, Ala-Seppala H, Frantzen J, Katila A, Kyllönen A, Maanpää HR, Posti J, Takala R, Tallus J, Tenovuo O
Kustantaja: ELSEVIER SCI LTD
Julkaisuvuosi: 2017
Journal: NeuroImage: Clinical
Tietokannassa oleva lehden nimi: NEUROIMAGE-CLINICAL
Lehden akronyymi: NEUROIMAGE-CLIN
Vuosikerta: 13
Aloitussivu: 174
Lopetussivu: 180
Sivujen määrä: 7
ISSN: 2213-1582
DOI: https://doi.org/10.1016/j.nicl.2016.11.016
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/25867175
We sought to investigate white matter abnormalities in mild traumatic brain injury (mTBI) using diffusion-weighted magnetic resonance imaging (DW-MRI). We applied a global approach based on tract-based spatial statistics skeleton as well as constrained spherical deconvolution tractography.DW-MRI was performed on 102 patients with mTBI within two months post-injury and 30 control subjects. A robust global approach considering only the voxels with a single-fiber configuration was used in addition to global analysis of the tract skeleton and probabilistic whole-brain tractography. In addition, we assessed whether the microstructural parameters correlated with age, time from injury, patient's outcome and white matter MRI hyperintensities. We found that whole-brain global approach restricted to single-fiber voxels showed significantly decreased fractional anisotropy (FA) (p = 0.002) and increased radial diffusivity (p = 0.011) in patients with mTBI compared with controls. The results restricted to single-fiber voxels were more significant and reproducible than those with the complete tract skeleton or the whole-brain tractography. FA correlated with patient outcomes, white matter hyperintensities and age. No correlation was observed between FA and time of scan post-injury. In conclusion, the global approach could be a promising imaging biomarker to detect white matter abnormalities following traumatic brain injury. (C) 2016 The Authors. Published by Elsevier Inc.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
