A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Synthesis of Aminoglycoside-2 '-O-Methyl Oligoribonucleotide Fusions
Tekijät: Granqvist L, Kraszewski A, Tähtinen V, Virta P
Kustantaja: MDPI AG
Kustannuspaikka: Basel
Julkaisuvuosi: 2017
Journal: Molecules
Tietokannassa oleva lehden nimi: MOLECULES
Lehden akronyymi: MOLECULES
Artikkelin numero: ARTN 760
Vuosikerta: 22
Numero: 5
Sivujen määrä: 13
ISSN: 1420-3049
DOI: https://doi.org/10.3390/molecules22050760
Verkko-osoite: http://www.mdpi.com/1420-3049/22/5/760
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/25773013
Phosphoramidite building blocks of ribostamycin (3 and 4), that may be incorporated at any position of the oligonucleotide sequence, were synthesized. The building blocks, together with a previously described neomycin-modified solid support, were applied for the preparation of aminoglycoside-2'-O-methyl oligoribonucleotide fusions. The fusions were used to clamp a single strand DNA sequence (a purine-rich strand of c-Myc promoter 1) to form triple helical 2'-O-methyl RNA/DNA-hybrid constructs. The potential of the aminoglycoside moieties to stabilize the triple helical constructs were studied by UV-melting profile analysis.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
