A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä

Parkinsonian Patients with Striatal Cribriform State Present Rapidly Progressive Axial Parkinsonism




TekijätLee SH, Lyoo CH, Cho H, Rinne JO, Lee MS

KustantajaS. Karger AG

KustannuspaikkaBasel

Julkaisuvuosi2017

JournalEuropean Neurology

Vuosikerta78

Numero3-4

Aloitussivu119

Lopetussivu124

Sivujen määrä6

ISSN0014-3022

eISSN1421-9913

DOIhttps://doi.org/10.1159/000479227

Verkko-osoitehttps://doi.org/10.1159/000479227


Tiivistelmä
AbstractOBJECTIVE:

To define the significance of striatal cribriform state (SCS) observed in patients with primary progressive parkinsonism.

METHODS:

We reviewed medical records and brain magnetic resonance imaging studies of 1,260 patients with primary progressive parkinsonism. We identified 23 patients with SCS and analyzed their clinical features.

RESULTS:

All 23 patients had rapidly progressive parkinsonism predominated by postural instability and gait disturbance. Clinical features of 18 of the 23 patients were compatible with progressive supranuclear palsy (PSP); 2 patients were compatible with parkinsonian type multiple system atrophy; 2 patients were compatible with mixed clinical features of both; and 1 patient had PSP-like clinical features.

CONCLUSIONS:

Most parkinsonian patients with SCS present rapidly progressive parkinsonism predominated by postural instability and gait disturbance. SCS observed in patients with parkinsonism does not seem to be a coincidental finding associated with the generalized cerebrovascular process.



Last updated on 2024-26-11 at 14:13