A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Parkinsonian Patients with Striatal Cribriform State Present Rapidly Progressive Axial Parkinsonism
Tekijät: Lee SH, Lyoo CH, Cho H, Rinne JO, Lee MS
Kustantaja: S. Karger AG
Kustannuspaikka: Basel
Julkaisuvuosi: 2017
Journal: European Neurology
Vuosikerta: 78
Numero: 3-4
Aloitussivu: 119
Lopetussivu: 124
Sivujen määrä: 6
ISSN: 0014-3022
eISSN: 1421-9913
DOI: https://doi.org/10.1159/000479227
Verkko-osoite: https://doi.org/10.1159/000479227
AbstractOBJECTIVE:
To define the significance of striatal cribriform state (SCS) observed in patients with primary progressive parkinsonism.
METHODS:We reviewed medical records and brain magnetic resonance imaging studies of 1,260 patients with primary progressive parkinsonism. We identified 23 patients with SCS and analyzed their clinical features.
RESULTS:All 23 patients had rapidly progressive parkinsonism predominated by postural instability and gait disturbance. Clinical features of 18 of the 23 patients were compatible with progressive supranuclear palsy (PSP); 2 patients were compatible with parkinsonian type multiple system atrophy; 2 patients were compatible with mixed clinical features of both; and 1 patient had PSP-like clinical features.
CONCLUSIONS:Most parkinsonian patients with SCS present rapidly progressive parkinsonism predominated by postural instability and gait disturbance. SCS observed in patients with parkinsonism does not seem to be a coincidental finding associated with the generalized cerebrovascular process.
