Parkinsonian Patients with Striatal Cribriform State Present Rapidly Progressive Axial Parkinsonism - UTU Research Portal

A1 Refereed original research article in a scientific journal

Parkinsonian Patients with Striatal Cribriform State Present Rapidly Progressive Axial Parkinsonism

Authors: Lee SH, Lyoo CH, Cho H, Rinne JO, Lee MS

Publisher: S. Karger AG

Publishing place: Basel

Publication year: 2017

Journal: European Neurology

Volume: 78

Issue: 3-4

First page : 119

Last page: 124

Number of pages: 6

ISSN: 0014-3022

eISSN: 1421-9913

DOI: https://doi.org/10.1159/000479227

Web address : https://doi.org/10.1159/000479227

Abstract

AbstractOBJECTIVE:

To define the significance of striatal cribriform state (SCS) observed in patients with primary progressive parkinsonism.

METHODS:

We reviewed medical records and brain magnetic resonance imaging studies of 1,260 patients with primary progressive parkinsonism. We identified 23 patients with SCS and analyzed their clinical features.

RESULTS:

All 23 patients had rapidly progressive parkinsonism predominated by postural instability and gait disturbance. Clinical features of 18 of the 23 patients were compatible with progressive supranuclear palsy (PSP); 2 patients were compatible with parkinsonian type multiple system atrophy; 2 patients were compatible with mixed clinical features of both; and 1 patient had PSP-like clinical features.

CONCLUSIONS:

Most parkinsonian patients with SCS present rapidly progressive parkinsonism predominated by postural instability and gait disturbance. SCS observed in patients with parkinsonism does not seem to be a coincidental finding associated with the generalized cerebrovascular process.