Substantial thalamostriatal dopaminergic defect in Unverricht-Lundborg disease

: Korja M, Kaasinen V, Lamusuo S, Parkkola R, Nagren K, Marttila RJ

Publisher: BLACKWELL PUBLISHING

: 2007

: Epilepsia

: EPILEPSIA

: 48

: 9

: 1768

: 1773

: 6

: 0013-9580

DOI: https://doi.org/10.1111/j.1528-1167.2007.01118.x

Conclusions: These results suggest that dopaminergic modulation at the level of the striatum and thalamus could be a crucial factor contributing to the symptoms of ULD. In the light of our data, we propose that ULD with dopamine dysfunction and dyskinetic symptoms shares certain pathophysiological mechanisms with classical movement disorders. Future studies are therefore warranted to study the effect of dopaminergic pharmacotherapy in ULD.