A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Substantial thalamostriatal dopaminergic defect in Unverricht-Lundborg disease
Tekijät: Korja M, Kaasinen V, Lamusuo S, Parkkola R, Nagren K, Marttila RJ
Kustantaja: BLACKWELL PUBLISHING
Julkaisuvuosi: 2007
Journal: Epilepsia
Tietokannassa oleva lehden nimi: EPILEPSIA
Lehden akronyymi: EPILEPSIA
Vuosikerta: 48
Numero: 9
Aloitussivu: 1768
Lopetussivu: 1773
Sivujen määrä: 6
ISSN: 0013-9580
DOI: https://doi.org/10.1111/j.1528-1167.2007.01118.x
Tiivistelmä
Conclusions: These results suggest that dopaminergic modulation at the level of the striatum and thalamus could be a crucial factor contributing to the symptoms of ULD. In the light of our data, we propose that ULD with dopamine dysfunction and dyskinetic symptoms shares certain pathophysiological mechanisms with classical movement disorders. Future studies are therefore warranted to study the effect of dopaminergic pharmacotherapy in ULD.
Conclusions: These results suggest that dopaminergic modulation at the level of the striatum and thalamus could be a crucial factor contributing to the symptoms of ULD. In the light of our data, we propose that ULD with dopamine dysfunction and dyskinetic symptoms shares certain pathophysiological mechanisms with classical movement disorders. Future studies are therefore warranted to study the effect of dopaminergic pharmacotherapy in ULD.
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