A1 Refereed original research article in a scientific journal

Substantial thalamostriatal dopaminergic defect in Unverricht-Lundborg disease




AuthorsKorja M, Kaasinen V, Lamusuo S, Parkkola R, Nagren K, Marttila RJ

PublisherBLACKWELL PUBLISHING

Publication year2007

JournalEpilepsia

Journal name in sourceEPILEPSIA

Journal acronymEPILEPSIA

Volume48

Issue9

First page 1768

Last page1773

Number of pages6

ISSN0013-9580

DOIhttps://doi.org/10.1111/j.1528-1167.2007.01118.x


Abstract
Conclusions: These results suggest that dopaminergic modulation at the level of the striatum and thalamus could be a crucial factor contributing to the symptoms of ULD. In the light of our data, we propose that ULD with dopamine dysfunction and dyskinetic symptoms shares certain pathophysiological mechanisms with classical movement disorders. Future studies are therefore warranted to study the effect of dopaminergic pharmacotherapy in ULD.



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