Oxycodone concentrations are greatly increased by the concomitant use of ritonavir or lopinavir/ritonavir

: Nieminen TH, Hagelberg NM, Saari TI, Neuvonen M, Neuvonen PJ, Laine K, Olkkola KT

Publisher: SPRINGER HEIDELBERG

: 2010

: European Journal of Clinical Pharmacology

: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

: EUR J CLIN PHARMACOL

: 10

: 66

: 10

: 977

: 985

: 9

: 0031-6970

DOI: https://doi.org/10.1007/s00228-010-0879-1

Ritonavir and lopinavir/ritonavir greatly increase the plasma concentrations of oral oxycodone in healthy volunteers and enhance its effect. When oxycodone is used clinically in patients during ritonavir and lopinavir/ritonavir treatment, reductions in oxycodone dose may be needed to avoid opioid-related adverse effects.