A1 Refereed original research article in a scientific journal

Oxycodone concentrations are greatly increased by the concomitant use of ritonavir or lopinavir/ritonavir



Authors: Nieminen TH, Hagelberg NM, Saari TI, Neuvonen M, Neuvonen PJ, Laine K, Olkkola KT

Publisher: SPRINGER HEIDELBERG

Publication year: 2010

Journal: European Journal of Clinical Pharmacology

Journal name in source: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Journal acronym: EUR J CLIN PHARMACOL

Number in series: 10

Volume: 66

Issue: 10

First page : 977

Last page: 985

Number of pages: 9

ISSN: 0031-6970

DOI: https://doi.org/10.1007/s00228-010-0879-1


Abstract
Ritonavir and lopinavir/ritonavir greatly increase the plasma concentrations of oral oxycodone in healthy volunteers and enhance its effect. When oxycodone is used clinically in patients during ritonavir and lopinavir/ritonavir treatment, reductions in oxycodone dose may be needed to avoid opioid-related adverse effects.



Last updated on 2024-26-11 at 20:08