A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Oxycodone concentrations are greatly increased by the concomitant use of ritonavir or lopinavir/ritonavir
Tekijät: Nieminen TH, Hagelberg NM, Saari TI, Neuvonen M, Neuvonen PJ, Laine K, Olkkola KT
Kustantaja: SPRINGER HEIDELBERG
Julkaisuvuosi: 2010
Journal: European Journal of Clinical Pharmacology
Tietokannassa oleva lehden nimi: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
Lehden akronyymi: EUR J CLIN PHARMACOL
Numero sarjassa: 10
Vuosikerta: 66
Numero: 10
Aloitussivu: 977
Lopetussivu: 985
Sivujen määrä: 9
ISSN: 0031-6970
DOI: https://doi.org/10.1007/s00228-010-0879-1
Tiivistelmä
Ritonavir and lopinavir/ritonavir greatly increase the plasma concentrations of oral oxycodone in healthy volunteers and enhance its effect. When oxycodone is used clinically in patients during ritonavir and lopinavir/ritonavir treatment, reductions in oxycodone dose may be needed to avoid opioid-related adverse effects.
Ritonavir and lopinavir/ritonavir greatly increase the plasma concentrations of oral oxycodone in healthy volunteers and enhance its effect. When oxycodone is used clinically in patients during ritonavir and lopinavir/ritonavir treatment, reductions in oxycodone dose may be needed to avoid opioid-related adverse effects.