NOVEL NON-NUCLEOSIDIC PHOSPHORAMIDITE BUILDING-BLOCKS FOR VERSATILE FUNCTIONALIZATION OF OLIGONUCLEOTIDES AT PRIMARY HYDROXY-GROUPS



: HOVINEN J, GUZAEV A, AZHAYEV A, LONNBERG H

Publisher: ROYAL SOC CHEMISTRY

: 1994

Journal of the Chemical Society. Perkin transactions 1

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

: J CHEM SOC PERK T 1

: 19

: 2745

: 2749

: 5

: 0300-922X

DOI: https://doi.org/10.1039/p19940002745


Synthesis of two non-nucleosidic phosphoramidite building blocks, 1a, b, that enable attachment of various tether groups to oligonucleotides at their 5'-terminus (or 1'-OH of 3'-deoxypsico-nucleoside units) is described. Introduction of these linkers during the oligonucleotide assembly on a solid support, and their subsequent derivatization upon deprotection, afforded amino-, carboxy-, and sulfanyl-alkyl-thethered oligonucleotides.



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