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NOVEL NON-NUCLEOSIDIC PHOSPHORAMIDITE BUILDING-BLOCKS FOR VERSATILE FUNCTIONALIZATION OF OLIGONUCLEOTIDES AT PRIMARY HYDROXY-GROUPS
Tekijät: HOVINEN J, GUZAEV A, AZHAYEV A, LONNBERG H
Kustantaja: ROYAL SOC CHEMISTRY
Julkaisuvuosi: 1994
Lehti:: Journal of the Chemical Society. Perkin transactions 1
Tietokannassa oleva lehden nimi: JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
Lehden akronyymi: J CHEM SOC PERK T 1
Numero: 19
Aloitussivu: 2745
Lopetussivu: 2749
Sivujen määrä: 5
ISSN: 0300-922X
DOI: https://doi.org/10.1039/p19940002745
Tiivistelmä
Synthesis of two non-nucleosidic phosphoramidite building blocks, 1a, b, that enable attachment of various tether groups to oligonucleotides at their 5'-terminus (or 1'-OH of 3'-deoxypsico-nucleoside units) is described. Introduction of these linkers during the oligonucleotide assembly on a solid support, and their subsequent derivatization upon deprotection, afforded amino-, carboxy-, and sulfanyl-alkyl-thethered oligonucleotides.
Synthesis of two non-nucleosidic phosphoramidite building blocks, 1a, b, that enable attachment of various tether groups to oligonucleotides at their 5'-terminus (or 1'-OH of 3'-deoxypsico-nucleoside units) is described. Introduction of these linkers during the oligonucleotide assembly on a solid support, and their subsequent derivatization upon deprotection, afforded amino-, carboxy-, and sulfanyl-alkyl-thethered oligonucleotides.
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