A1 Refereed original research article in a scientific journal
NOVEL NON-NUCLEOSIDIC PHOSPHORAMIDITE BUILDING-BLOCKS FOR VERSATILE FUNCTIONALIZATION OF OLIGONUCLEOTIDES AT PRIMARY HYDROXY-GROUPS
Authors: HOVINEN J, GUZAEV A, AZHAYEV A, LONNBERG H
Publisher: ROYAL SOC CHEMISTRY
Publication year: 1994
Journal:: Journal of the Chemical Society. Perkin transactions 1
Journal name in source: JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
Journal acronym: J CHEM SOC PERK T 1
Issue: 19
First page : 2745
Last page: 2749
Number of pages: 5
ISSN: 0300-922X
DOI: https://doi.org/10.1039/p19940002745
Abstract
Synthesis of two non-nucleosidic phosphoramidite building blocks, 1a, b, that enable attachment of various tether groups to oligonucleotides at their 5'-terminus (or 1'-OH of 3'-deoxypsico-nucleoside units) is described. Introduction of these linkers during the oligonucleotide assembly on a solid support, and their subsequent derivatization upon deprotection, afforded amino-, carboxy-, and sulfanyl-alkyl-thethered oligonucleotides.
Synthesis of two non-nucleosidic phosphoramidite building blocks, 1a, b, that enable attachment of various tether groups to oligonucleotides at their 5'-terminus (or 1'-OH of 3'-deoxypsico-nucleoside units) is described. Introduction of these linkers during the oligonucleotide assembly on a solid support, and their subsequent derivatization upon deprotection, afforded amino-, carboxy-, and sulfanyl-alkyl-thethered oligonucleotides.
UTU Research Portal