Global expression of AMACR transcripts predicts risk for prostate cancer - a systematic comparison of AMACR protein and mRNA expression in cancerous and noncancerous prostate



: Alinezhad S, Vaananen RM, Ochoa NT, Vertosick EA, Bjartell A, Bostrom PJ, Taimen P, Pettersson K

Publisher: BIOMED CENTRAL LTD

: 2016

 BMC Urology

: BMC UROLOGY

: BMC UROL

: ARTN 10

: 16

: 10

: 1471-2490

DOI: https://doi.org/10.1186/s12894-016-0128-8


Conclusions: AMACR transcripts were detected in all RP-PCa and RP-Be samples but not in non-cancerous CP samples, which suggest a global increase of AMACR expression in cancerous prostates. Therefore patients with false negative biopsies might benefit from an AMACR mRNA measurement when assessing their cancer risk.



AMACR, Biomarker, mRNA expression, Radical prostatectomy and cystoprostatectomy



Last updated on 26/11/2024 10:22:35 PM