Global expression of AMACR transcripts predicts risk for prostate cancer - a systematic comparison of AMACR protein and mRNA expression in cancerous and noncancerous prostate - UTU Research Portal

A1 Refereed original research article in a scientific journal

Global expression of AMACR transcripts predicts risk for prostate cancer - a systematic comparison of AMACR protein and mRNA expression in cancerous and noncancerous prostate

Authors: Alinezhad S, Vaananen RM, Ochoa NT, Vertosick EA, Bjartell A, Bostrom PJ, Taimen P, Pettersson K

Publisher: BIOMED CENTRAL LTD

Publication year: 2016

Journal: BMC Urology

Journal name in source: BMC UROLOGY

Journal acronym: BMC UROL

Article number: ARTN 10

Volume: 16

Number of pages: 10

ISSN: 1471-2490

DOI: https://doi.org/10.1186/s12894-016-0128-8(external)

Abstract

Conclusions: AMACR transcripts were detected in all RP-PCa and RP-Be samples but not in non-cancerous CP samples, which suggest a global increase of AMACR expression in cancerous prostates. Therefore patients with false negative biopsies might benefit from an AMACR mRNA measurement when assessing their cancer risk.