Global expression of AMACR transcripts predicts risk for prostate cancer - a systematic comparison of AMACR protein and mRNA expression in cancerous and noncancerous prostate - UTU Tutkimustietojärjestelmä

A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä

Global expression of AMACR transcripts predicts risk for prostate cancer - a systematic comparison of AMACR protein and mRNA expression in cancerous and noncancerous prostate

Tekijät: Alinezhad S, Vaananen RM, Ochoa NT, Vertosick EA, Bjartell A, Bostrom PJ, Taimen P, Pettersson K

Kustantaja: BIOMED CENTRAL LTD

Julkaisuvuosi: 2016

Journal: BMC Urology

Tietokannassa oleva lehden nimi: BMC UROLOGY

Lehden akronyymi: BMC UROL

Artikkelin numero: ARTN 10

Vuosikerta: 16

Sivujen määrä: 10

ISSN: 1471-2490

DOI: https://doi.org/10.1186/s12894-016-0128-8

Tiivistelmä

Conclusions: AMACR transcripts were detected in all RP-PCa and RP-Be samples but not in non-cancerous CP samples, which suggest a global increase of AMACR expression in cancerous prostates. Therefore patients with false negative biopsies might benefit from an AMACR mRNA measurement when assessing their cancer risk.